Journal: Cancer Cytopathology

Article Title: Inter‐ and intraobserver agreement in whole‐slide digital ThinPrep samples of low‐grade squamous lesions of the cervix uteri with known high‐risk HPV status: A multicentric international study

doi: 10.1002/cncy.22624

Figure Lengend Snippet: Heat map summarizing all answers in both rounds according to diagnoses. ASC‐H indicates atypical squamous cells – cannot exclude high‐grade squamous intraepithelial lesion; ASC‐US, atypical squamous cells – undetermined significance; HR HPV, high‐risk human papilloma virus; HSIL, high‐grade squamous intraepithelial lesion; LSIL, low‐grade squamous intraepithelial lesion; NILM, negative for intraepithelial lesion or malignancy.

Article Snippet: In the analysis of the College of American Pathologists PAP Education program LSIL was misclassified in 2.4% of cases and ThinPrep LSIL slides were more likely to be misclassified than SurePath LSIL slides.

Techniques: Virus

Journal: Cancer Cytopathology

Article Title: Inter‐ and intraobserver agreement in whole‐slide digital ThinPrep samples of low‐grade squamous lesions of the cervix uteri with known high‐risk HPV status: A multicentric international study

doi: 10.1002/cncy.22624

Figure Lengend Snippet: Fleiss’ kappas/Kendall’s coefficients in total and in all three TBS categories according to the first and second rounds

Article Snippet: In the analysis of the College of American Pathologists PAP Education program LSIL was misclassified in 2.4% of cases and ThinPrep LSIL slides were more likely to be misclassified than SurePath LSIL slides.

Techniques:

Journal: Cancer Cytopathology

Article Title: Inter‐ and intraobserver agreement in whole‐slide digital ThinPrep samples of low‐grade squamous lesions of the cervix uteri with known high‐risk HPV status: A multicentric international study

doi: 10.1002/cncy.22624

Figure Lengend Snippet: Kendall’s coefficients in the first round without HR HPV status and in the second round with HR HPV status knowledge in all cases and according to TBS categories. ASC‐US indicates atypical squamous cells – undetermined significance; HR HPV, high‐risk human papilloma virus; LSIL, low‐grade squamous intraepithelial lesion; NILM, negative for intraepithelial lesion or malignancy; TBS, The Bethesda System for Reporting Cervical Cytology.

Article Snippet: In the analysis of the College of American Pathologists PAP Education program LSIL was misclassified in 2.4% of cases and ThinPrep LSIL slides were more likely to be misclassified than SurePath LSIL slides.

Techniques: Virus

Journal: Cancer Cytopathology

Article Title: Inter‐ and intraobserver agreement in whole‐slide digital ThinPrep samples of low‐grade squamous lesions of the cervix uteri with known high‐risk HPV status: A multicentric international study

doi: 10.1002/cncy.22624

Figure Lengend Snippet: Fleiss´ kappa values in the first round without HR HPV status and in the second round with HR HPV status knowledge in all cases and according to TBS categories. ASC‐US indicates atypical squamous cells – undetermined significance; HR HPV, high‐risk human papilloma virus; LSIL, low‐grade squamous intraepithelial lesion; NILM, negative for intraepithelial lesion or malignancy; TBS, The Bethesda System for Reporting Cervical Cytology.

Article Snippet: In the analysis of the College of American Pathologists PAP Education program LSIL was misclassified in 2.4% of cases and ThinPrep LSIL slides were more likely to be misclassified than SurePath LSIL slides.

Techniques: Virus

Journal: International journal of cancer

Article Title: Proof-of-principle study of a novel cervical screening and triage strategy: computer-analyzed cytology to decide which HPV-positive women are likely to have ≥CIN2

doi: 10.1002/ijc.30456

Figure Lengend Snippet: ROC curve for severity score, with area under the curve (AUC with 95% confidence interval), and comparison of severity score cut-point to conventionally-read cytology (≥ASC-US, ≥HSIL) thresholds. Figure 3a. All high-risk HPV-positive, AUC = 0.73 (0.69, 0.78); Figure 3b. HPV16, AUC = 0.71 (0.61, 0.81); Figure 3c. HPV18/45, AUC = 0.84 (0.74, 0.93); Figure 3d. HPV31/33/52/58, AUC = 0.73 (0.63, 0.83); Figure 3e. HPV35/39/51/56/59/66/68, AUC = 0.66 (0.55, 0.77). The results indicate that in this referral population, the computer-generated severity score yielded discrimination of cases of ≥CIN2 versus non-cases with a combination of sensitivity and specificity similar to conventional cytologic results of ASC-US+ versus NILM. The inverted triangle is to denote the hypothetical choice of a cutpoint to simulate a standard reading of the ThinPrep cytology slide at an ASC-US threshold.

Article Snippet: The archived ThinPrep slides were scanned at BD (North Carolina) in a few large batches or “run sets”.

Techniques: Generated